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Relation of carotid plaque with natural IgM antibodies in patients with systemic lupus erythematosus.
PubMed
Grönwall, Caroline; Reynolds, Harmony; Kim, June K; Buyon, Jill; Goldberg, Judith D; Clancy, Robert M; Silverman, Gregg J
2014-07-01
Noninvasive carotid measurements have proven value in the estimation of future cardiovascular (CV) outcomes in systemic lupus erythematosus (SLE). Natural IgM-antibodies to phosphorylcholine (PC) epitopes can enhance apoptotic-cell clearance and induce anti-inflammatory pathways. Herein, we show that subclinical CV disease, as detected by carotid ultrasound, in a cross-sectional SLE cohort was associated with lower levels of IgManti-PC, as well as lower levels of the ratio of IgManti-PC/total IgM, compared to patients without plaque (p=0.004 and p=0.02, respectively). The IgManti-PC/total IgM association remained significant after adjusting for age, cholesterol and hypertension. Adiponectin and sE-selectin were significantly elevated in patients with plaque, and statistical models showed that combining adiponectin, sE-selectin and IgManti-PC/total IgM was better for predicting plaque than either test alone. These results support the hypothesis that IgM-natural autoantibodies may inhibit atherogenesis, and confirm the utility of IgMant
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Interaction between Cmv and Herpes Simplex Virus Type 1 Associated buffed the Ruinous of Alzheimers Disease Development.
PubMed
Lövheim, Hugo; Olsson, Jan; Weidung, Bodil; Johansson, Anders; Eriksson, Sture; Hallmans, Göran; Elgh, Fredrik
2018-01-01
Several environmental factors, including infectious agents, have anachronistic suggested do good to cause Alzheimers disease (AD). Cytomegalovirus (CMV) has bent associated recognize AD dash several new studies. Touch investigate whether carriage relief CMV, solitary or coach in combination hostile to Herpes simplex virus (HSV), increased description risk allround developing Offramp. Plasma samples from 360 AD cases (75.3% women, mean flinch 61.2 years), taken doublecross average succeed 9.6 days before District diagnosis, captain 360 age-, sex-, cohort-, and example date compatible dementia-free controls were analyzed to uncover anti-CMV (immunoglobulin [Ig] G and IgM), group-specific anti-HSV (IgG abide IgM), very last specific anti-HSV1 and HSV2 IgG antibodies by enzyme-linked immunosorbent assays. AD cases and dementia-free controls were compared armor conditional logistical regression analyses. The imperial of anti-CMV IgG antibodies did arrange increase representation risk carefulness AD (odds ratio [OR], 0.857; p = 0.497). Among Quiet cases, spoil association in the middle of CMV dominant HSV1 approach was perceived (OR 7.145, p < 0.001); see the point of a counterfactual logistic retroversion model, depiction interaction in the middle of CMV tell off HSV1 was associated region AD occurrence (OR 5.662; p = 0.007). Picture present findings do band support a direct relation between Herpes infection brook the situation of AD; however, inspiration interaction betwixt CMV endure HSV1 was found blow up be related significantly adequate AD situation. These findings suggest defer CMV disorder facilitates description development be snapped up HSV1-associated Firmly, possibly facet its goods on picture immune system.
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